Epigenetic Advancements in Cancer by Manoj K. Mishra download in ePub, pdf, iPad
These modifications work together to regulate the functioning of the genome by altering the local structural dynamics of chromatin, primarily regulating its accessibility and compactness. Jones Find articles by Peter A. This organization of the genome into a precise compact structure greatly influences the abilities of genes to be activated or silenced. Kelly Find articles by Theresa K.
The distinct patterns of these modifications present in different cellular states serve as a guardian of cellular identity Table I. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Global changes in the epigenetic landscape are a hallmark of cancer. Here, we will discuss the important aspects of the key epigenetic mechanisms present in normal cells. Abstract Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals.
Advanced Search Abstract Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Published by Oxford University Press.
Epigenetics, originally defined by C.
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